In this study, children with cancer and healthy students between the ages of 9 and 13 were investigated in terms of depression status. A demographic data form and the Children’s Depression Inventory were given to both groups. The research group consisted of 50 children with cancer who were followed up in pediatric hematology and oncology outpatient clinics at Ankara University. The control group was comprised of 50 healthy students who attended Turkozu Timur Primary School. It was found that there were significant differences between depression scores of children with cancer and children that are healthy. Children with cancer have higher depression scores than healthy students.