OBJECTIVES: Emotional responses to pain are known to play an important role in the development and maintenance of pain. In order to better understand the role that pain anxiety plays in chronic pain, as well as to evaluate treatments that might effectively treat it, reliable and valid measures of pain anxiety are needed. Thus, the aim of this study is to provide additional evidence regarding the psychometric properties of the Child Pain Anxiety Symptoms Scale (CPASS) in a sample of adolescents. METHODS: 357 adolescents aged 12 to 19 years completed measures of pain anxiety (CPASS), pain-related catastrophizing (PCS-C), anxiety sensitivity (CASI) and sleep quality (NRS-Sleep). We used Confirmatory Factor Analyses (CFA) to evaluate the factor structure of the CPASS items. We also tested the reliability and validity of the CPASS scores. RESULTS: CFA suggested a 4-factor structure with a single higher order factor (CFI=0.91, TLI=0.95, RMSEA=0.078). The total score of CPASS showed good internal consistency (alpha=0.87) and adequate validity as evidenced by (1) moderate to high correlations between CPASS-PCS-C (r=0.74, P<0.001) and CPASS-CASI (r=0.48, P<0.001) and (2) the magnitude of the correlations between CPASS-PCS-C and CPASS-CASI being significantly greater than that between CPASS and NRS-Sleep (z=14.70 and 8.96, respectively; P<0.001). DISCUSSION: The findings support the reliability and validity of the CPASS as a measure of pain-related anxiety in adolescents.