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External validity of the pediatric cardiac quality of life inventory

Journal title
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Publication year
Marino, B. S.; Drotar, D.; Cassedy, A.; Davis, R.; Tomlinson, R. S.; Mellion, K.; Mussatto, K.; Mahony, L.; Newburger, J. W.; Tong, E.; Cohen, M. I.; Helfaer, M. A.; Kazak, A. E.; Wray, J.; Wernovsky, G.; Shea, J. A.; Ittenbach, R.

PURPOSE: The Pediatric Cardiac Quality of Life Inventory (PCQLI) is a disease-specific, health-related quality of life (HRQOL) measure for pediatric heart disease (HD). The purpose of this study was to demonstrate the external validity of PCQLI scores. METHODS: The PCQLI development site (Development sample) and six geographically diverse centers in the United States (Composite sample) recruited pediatric patients with acquired or congenital HD. Item response option variability, scores [Total (TS); Disease Impact (DI) and Psychosocial Impact (PI) subscales], patterns of correlation, and internal consistency were compared between samples. RESULTS: A total of 3,128 patients and parent participants (1,113 Development; 2,015 Composite) were analyzed. Response option variability patterns of all items in both samples were acceptable. Inter-sample score comparisons revealed no differences. Median item-total (Development, 0.57; Composite, 0.59) and item-subscale (Development, DI 0.58, PI 0.59; Composite, DI 0.58, PI 0.56) correlations were moderate. Subscale-subscale (0.79 for both samples) and subscale-total (Development, DI 0.95, PI 0.95; Composite, DI 0.95, PI 0.94) correlations and internal consistency (Development, TS 0.93, DI 0.90, PI 0.84; Composite, TS 0.93, DI 0.89, PI 0.85) were high in both samples. CONCLUSION: PCQLI scores are externally valid across the US pediatric HD population and may be used for multi-center HRQOL studies.

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