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Liver transplantation for pediatric inherited metabolic disorders: Considerations for indications, complications, and perioperative management

Journal title
Pediatric transplantation
Publication year
2016
Author(s)
Oishi, K.; Arnon, R.; Wasserstein, M. P.; Diaz, G. A.
Pages
756-69
Volume
20
Number
6

LT is an effective therapeutic option for a variety of IEM. This approach can significantly improve the quality of life of patients who suffer from severe disease manifestations and/or life-threatening metabolic decompensations despite medical/dietary management. Due to the significant risks for systemic complications from surgical stressors, careful perioperative management is vital. Even after LT, some disorders require long-term dietary restriction, medical management, and monitoring of metabolites. Successful liver transplant for these complex disorders can be achieved with disease- and patient-specific strategies using a multidisciplinary approach. In this article, we review indications, complications, perioperative management, and long-term follow-up recommendations for IEM that are treatable with LT.

Research abstracts