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Miconazole buccal gel and risk for systemic bleeding: how certain topical formula can interfere with anticoagulants

Journal title
Acta clinica Belgica
Publication year
2015
Author(s)
De Pauw, A.; De Backer, T.
Pages
121-3
Volume
70
Number
2

The association of miconazole and oral anticoagulants should be carried out with great caution because of potentially serious side effects. This phenomenon is well known in the case of systemic administration of miconazole, but there is limited awareness that also topical oral administration of miconazole can provoke these effects. In this paper we describe four patients followed at the Cardiology Department of the Ghent University Hospital, who used an oral mucosal miconazole preparation, and who developed an increased international normalized ratio.

Research abstracts