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Zika virus impairs growth in human neurospheres and brain organoids

Journal title
Science (New York, N.Y.)
Publication year
2016
Author(s)
Garcez, P. P.; Loiola, E. C.; Madeiro da Costa, R.; Higa, L. M.; Trindade, P.; Delvecchio, R.; Nascimento, J. M.; Brindeiro, R.; Tanuri, A.; Rehen, S. K.
Pages
816-8
Volume
352
Number
6287

Since the emergence of Zika virus (ZIKV), reports of microcephaly have increased considerably in Brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. We examined the effects of ZIKV infection in human neural stem cells growing as neurospheres and brain organoids. Using immunocytochemistry and electron microscopy, we showed that ZIKV targets human brain cells, reducing their viability and growth as neurospheres and brain organoids. These results suggest that ZIKV abrogates neurogenesis during human brain development.

Research abstracts